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Updated: May 20, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
[Hypocretin disturbance and sleep disorders]
1Neurologie, Hôpital Gui de Chauliac, 80, avenue Augustin Fliche, 34295 Montpellier cedex. mbilliard@wanadoo.fr
Abstract:
The hypothalamic hypocretin (orexin) system plays a crucial role in the regulation of sleep and wakefulness. The strongest evidence is the fact that the primary sleep disorder narcolepsy is caused by disrupted hypocretin signaling in humans as well as in various animal models. Today there is growing interest in the role of hypocretin defects in sleep disorders associated with neurodegenerative diseases. One of the most controversial issues is the functional relevance of partial hypocretin defects in these disorders.
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