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Gross Anatomy of the Liver

Gross Anatomy of the Liver

The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is covered...

Liver Physiology

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...

Liver Histology

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...

Hepatic Portal System

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

Major Organs of the Digestive System

Major Organs of the Digestive System

The digestive system is responsible for the ingestion of food, secretion of enzymes, mixing and digesting food, absorption of the nutrients and defecation. The human digestive system consists of two major parts: the gastrointestinal tract and the accessory digestive organs.
Gastrointestinal tract:

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Updated: May 20, 2026

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

Published on: November 10, 2011

[The liver].

Dominique Franco¹, Karim Si-Tayeb

¹Chirurgie digestive et visérale, Hôpital Antoine-Béclère, 157 rue de la Porte-de-Trivaux - 92141 Clamart cedex. dominique.franco@abc.aphp.fr

Bulletin De L'Academie Nationale De Medecine

|July 21, 2012

Summary

This summary is machine-generated.

Engineered livers using decellularized scaffolds and stem cells show promise for future transplantation. This approach could overcome limitations of current hepatocyte transplantation methods.

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Related Experiment Videos

Last Updated: May 20, 2026

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

Published on: November 10, 2011

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Area of Science:

Regenerative Medicine
Tissue Engineering
Hepatology

Context:

Hepatocyte transplantation faces challenges with cell integration and proliferation.
Decellularized liver scaffolds preserve vascular networks and extracellular matrix.
Whole organ engineering is a developing field in regenerative medicine.

Purpose:

To engineer functional liver organs using decellularized scaffolds.
To investigate the potential of auto-constructed livers for transplantation.
To overcome limitations of current hepatocyte transplantation.

Summary:

Whole livers can be decellularized to create scaffolds with preserved architecture.
These scaffolds can be repopulated with various cell types, including stem cells.
Reconstituted organs demonstrate functionality and transplantability in animal models.

Impact:

Auto-constructed livers offer a potential alternative to conventional liver grafts.
This technology could advance treatments for liver failure.
Enables the engineering of complex, functional organs from scaffolds.