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An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
Published on: May 21, 2019
Lung cancer: microRNA and target database.
Challa Kiran1, Ponnala Deepika
1Centre for Cellular and Molecular Biology, India. challa.kiranbio7@gmail.com
Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|July 21, 2012
Summary
This review compiles a database of human microRNAs (miRNAs) and their target genes implicated in lung cancer. These findings highlight miRNAs as potential diagnostic markers and therapeutic targets for lung cancer.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression.
- miRNAs play critical roles in cellular processes including cell growth, differentiation, and apoptosis.
- Dysregulation of miRNAs is implicated in tumorigenesis, particularly in lung cancer.
Purpose of the Study:
- To compile a comprehensive database of human miRNAs involved in lung cancer.
- To identify target genes and associated pathways for these miRNAs.
- To provide miRNA sequences and chromosomal locations.
Main Methods:
- Literature review and data compilation from multiple databases (microCosm, PhenomiR, mir2Disease).
- Identification of miRNA sequences and chromosomal locations.
- Analysis of target gene information and associated biological pathways (e.g., cell cycle, apoptosis, angiogenesis).
Main Results:
- A curated database of human miRNAs associated with lung cancer was established.
- Target genes and their involvement in key cancer-related pathways were detailed.
- Sequence and chromosomal location data for numerous miRNAs were provided.
Conclusions:
- miRNAs are significantly involved in lung cancer development.
- The compiled database serves as a valuable resource for lung cancer research.
- miRNAs show promise as diagnostic biomarkers and therapeutic targets for lung cancer.
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