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Updated: May 20, 2026
11:52
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
In vitro Antimicrobial Activity of SinuSurf™
Jennifer M Kofonow1, Nithin D Adappa
1Division of Rhinology, Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Summary
SinuSurf, a sinonasal surfactant, significantly reduced bacterial growth and biofilm formation in vitro. When combined with antibiotics, it enhanced eradication of resistant bacteria like MRSA and Pseudomonas aeruginosa.
Area of Science:
- Otorhinolaryngology
- Microbiology
- Infectious Diseases
Background:
- Recalcitrant chronic rhinosinusitis (CRS) often involves bacterial biofilms.
- Topical surfactant therapy shows promise in managing CRS.
Purpose of the Study:
- To evaluate the in vitro antibacterial efficacy of SinuSurf, a sinonasal surfactant.
- To assess SinuSurf's impact on antibiotic effectiveness against common CRS pathogens.
Main Methods:
- Bacterial cultures (MRSA, PA) were treated with SinuSurf and antibiotics (mupirocin, gentamicin).
- Colony-forming units (CFUs) and biofilm formation were quantified.
- Effectiveness was tested in contaminated sinus irrigation bottles.
Main Results:
- SinuSurf alone achieved significant log reductions in MRSA and PA CFUs.
- SinuSurf enhanced antibiotic efficacy, leading to complete bacterial eradication at lower concentrations.
- SinuSurf reduced MRSA and PA biofilm formation by 83% and 76%, respectively.
- SinuSurf significantly reduced bacterial contamination in irrigation bottles.
Conclusions:
- SinuSurf demonstrates potent in vitro antibacterial and anti-biofilm activity.
- Combining SinuSurf with topical antibiotics improves treatment effectiveness for recalcitrant CRS.
- SinuSurf holds potential as an adjunct therapy for sinonasal infections.
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