Related Experiment Video
Updated: May 20, 2026
23:56
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
Published on: October 31, 2010
Towards an HIV cure: a global scientific strategy
Nature Reviews. Immunology
|July 21, 2012
Summary
A cure for HIV is increasingly seen as feasible due to advances in understanding HIV persistence. An international expert group outlined key research goals for an HIV cure strategy.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Background:
- Antiretroviral therapy (ART) has limitations in achieving a complete HIV cure.
- Understanding HIV persistence during effective ART is crucial for developing curative strategies.
- There is a growing consensus that an HIV cure is both necessary and achievable.
Approach:
- Convened an international expert group under the International AIDS Society.
- Identified key research priorities across basic, translational, and clinical science.
- Developed a strategic research agenda focused on achieving an HIV cure.
Key Points:
- The need for an HIV cure is driven by ART limitations and improved understanding of viral persistence.
- A feasible scientific strategy requires coordinated international research efforts.
- Prioritization of research areas is essential for efficient progress towards an HIV cure.
Conclusions:
- An international, multidisciplinary research strategy is recommended to pursue an HIV cure.
- Key goals for basic, translational, and clinical research have been identified.
- This expert-driven strategy aims to guide the global scientific community in the quest for an HIV cure.
Related Concept Videos
01:10Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
01:26Human Virome
The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
01:26Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...