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A prognostic score based on clinical factors and biomarkers for advanced non-small cell lung cancer
Jaume Trapé1, Jesus Montesinos, Sílvia Catot
1Laboratory Medicine Service, Althaia, Xarxa Assistencial Universitària de Manresa, Manresa, Barcelona, Spain. jtrape@althaia.cat
Aims:
The objective of the present study is to determine the prognostic value of clinical variables and biomarkers in patients with advanced stages of NSCLC and establish a prognostic classification of these patients.
Methods:
For 135 patients with advanced NSCLC we determined their clinical variables and their levels of CEA, CA 125, CYFRA 21-1, albumin, LDH, erythrosedimentation and leukocytes.
Results:
Multivariate analysis identified PS (ECOG) >1, metastases, no anti-neoplastic treatment, CA 125 >35 U/mL, CYFRA 21-1 >3.3 ng/mL and leukocytes >10'000/µL, as independent prognostic factors for survival. Patients were classified into 3 groups according to the number of adverse prognostic factors (APF). One point was assigned for each APF, except for chemotherapy treatment. Patients with 0-1 APF represented our reference group: patients with 2-3 APF had HR=2.7 (95% CI: 1.5-4.6), while patients with 4-5 APF had HR=8.8 (95% CI: 4.6-16.8). This "score" maintained the differences between risk groups both in patients who received antineoplastic treatment and in those who did not.
Conclusion:
The application of a score that includes clinical data and biomarkers may improve the prognostic classification of NSCLC patients.
