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Role of sexually-transmitted infections in the structural and functional reorganization of the prostate

E L Lushnikova1, L M Nepomnyashchikh, N A Abdullaev

  • 1Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru

Bulletin of Experimental Biology and Medicine
|July 21, 2012
PubMed

Insights

Sexually transmitted infections cause significant cellular changes in the prostate. Chronic prostatitis with infections like Mycoplasmataceae and Chlamydia trachomatis leads to destructive and autophagic processes in secretory cells.

Area of Science:

  • Urology
  • Pathology
  • Microbiology

Background:

  • Chronic prostatitis is often linked to sexually transmitted infections.
  • Understanding the cellular impact of these infections is crucial for treatment.

Purpose of the Study:

  • To investigate intracellular reorganization in prostatic secretory epitheliocytes.
  • To examine the effects of specific sexually transmitted infections on prostate tissue.

Main Methods:

  • Studied secretory epitheliocytes from main, intermediate, and periurethral prostatic glands.
  • Analyzed changes under conditions of chronic prostatitis and sexually transmitted infections.

Main Results:

  • Persistence of Mycoplasmataceae and Chlamydia trachomatis stimulated destructive and autophagic processes.
  • Significant intracellular reorganization observed in smooth-muscle cells, including ultrastructural destruction and myofilament lysis.

Conclusions:

  • Sexually transmitted infections induce significant cellular damage in the prostate.
  • Microbial persistence triggers destructive and autophagic pathways in prostatic epitheliocytes and smooth muscle cells.

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