Related Experiment Videos

Influence of severe sarcopenia on cardiovascular risk factors in nonobese men

Takashi Abe1, Robert S Thiebaud, Jeremy P Loenneke

  • 1Department of Health, Exercise Sciences & Recreation Management, University of Mississippi, Oxford, MS 38677, USA. t12abe@gmail.com

Metabolic Syndrome and Related Disorders
|July 24, 2012
PubMed

Insights

Severe and moderate sarcopenia may impact high-density lipoprotein cholesterol (HDL-C) levels, though values remain within normal clinical ranges. This study investigated sarcopenia

Area of Science:

  • Gerontology and Geriatric Medicine
  • Cardiovascular Health
  • Metabolic Health

Background:

  • The impact of severe sarcopenia on cardiovascular risk factors remains largely unknown.
  • This study aimed to investigate the relationship between sarcopenia severity and cardiovascular risk markers in men.
  • Exclusion criteria included clinically relevant diseases and high body fat percentage (>25%) to focus on sarcopenia's effects.

Purpose of the Study:

  • To examine the influence of severe and moderate sarcopenia on selected cardiovascular risk factors in middle-aged and older men.
  • To assess how skeletal muscle mass index (SM) relates to lipid profiles and blood pressure.

Main Methods:

  • Sarcopenia was defined using skeletal muscle mass (SM) index: 1-2 SD below mean (moderate) or <2 SDs below mean (severe).
  • Ultrasound measured subcutaneous fat and muscle thickness to estimate SM, body fat percentage, and fat-free mass.
  • Fasting blood samples analyzed serum total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C); blood pressure was also measured.

Main Results:

  • Total cholesterol (TC) was lower in moderate and severe sarcopenia groups compared to the normal group.
  • The TC:HDL-C ratio was lower in both sarcopenia groups.
  • After adjusting for covariates, HDL-C was lower in sarcopenia groups, with a high prevalence of moderate HDL-C in these groups.

Conclusions:

  • Moderate and severe sarcopenia appear to influence high-density lipoprotein cholesterol (HDL-C) levels.
  • Despite observed influences, HDL-C levels in sarcopenic men remained within clinically normal ranges.
  • Further research is warranted to understand the clinical implications of these findings.
Abstract

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...