[Low-affinity Fcγ receptor IIa gene polymorphism and dengue bleeding disorder]
Gissel García1, Daniel González, Lizet Sánchez
1Departamento de Virología, Centro Colaborador para el estudio del Dengue y su Vector, Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba. gmd@ipk.sld.cu
Introduction:
The pathophysiological changes that determine the severity of dengue are still not well known, therefore it is important to study the probable relationship with the host genetic.
Methods:
We analyzed the possible association between the FcγRIIa polymorphism and clinical signs in individuals who suffered dengue infection in 2006, using contingency tables.
Results:
We found that bleeding was significantly associated to FcγRIIa H/H131 genotype (80%).
Conclusion:
Our results suggest that in clinical dengue infection the bleeding could be associated to FcγRIIa H/H131 genotype.
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