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Updated: May 20, 2026

Dissection of the Endolymphatic Sac from Mice
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Published on: March 29, 2021

What is endosalpingiosis?

Lucy Prentice1, Alistair Stewart, Seema Mohiuddin

  • 1Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. prentice.lucy@gmail.com

Fertility and Sterility
|July 24, 2012
PubMed
Summary

Endosalpingiosis affects postmenopausal women more than previously thought and does not appear linked to infertility or chronic pelvic pain, unlike endometriosis. Concurrent endometriosis occurs in 34% of endosalpingiosis cases.

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Area of Science:

  • Gynecologic pathology
  • Reproductive endocrinology
  • Surgical oncology

Background:

  • Endosalpingiosis is a poorly understood condition.
  • Its relationship with endometriosis, infertility, and chronic pelvic pain requires clarification.
  • Previous studies have not adequately characterized endosalpingiosis demographics.

Purpose of the Study:

  • To describe the demographics and clinical presentation of endosalpingiosis.
  • To compare endosalpingiosis with endometriosis regarding infertility and chronic pelvic pain.
  • To investigate the association between endosalpingiosis and gynecologic malignancy.

Main Methods:

  • Retrospective analysis of hospital records.
  • Inclusion of women with histologic diagnoses of endosalpingiosis, endometriosis, or neither.
  • Comparison of clinical outcomes including infertility and chronic pelvic pain.

Main Results:

  • 40% of endosalpingiosis cases occurred in postmenopausal women.
  • Endometriosis was significantly associated with infertility and chronic pelvic pain.
  • Endosalpingiosis showed no significant association with infertility or chronic pelvic pain.
  • Premenopausal women with endosalpingiosis had a higher incidence of gynecologic malignancy.

Conclusions:

  • Endosalpingiosis affects postmenopausal women more frequently than previously reported.
  • Endosalpingiosis and endometriosis can coexist but have distinct clinical presentations.
  • Endosalpingiosis is not a variant of endometriosis.