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Updated: May 20, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Structural simplification of bioactive natural products with multicomponent synthesis. 4.
Igor V Magedov1, Artem S Kireev, Aaron R Jenkins
1Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA. imagedov@nmt.edu
Abstract:
4H-Pyrano-[2,3-b]naphthoquinone is a structural motif commonly found in natural products manifesting anticancer activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes, we developed a compound library based on this heterocyclic scaffold. We found that several library members displayed low micromolar antiproliferative activity and induced apoptosis in human cancer cells. Selected compounds showed promising activity against cancer cell lines resistant to proapoptotic stimuli, demonstrating their potential in treating cancers with dismal prognoses.
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