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Related Experiment Video

Updated: May 20, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
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Published on: September 16, 2017

[Estimating elapsed time of brain hemorrhage using computed tomography value-based parameters].

Ken Furuya1, Shinji Akiyama, Kouji Nakamura

  • 1Department of Radiology, Municipal Kofu Hospital.

Nihon Hoshasen Gijutsu Gakkai Zasshi
|July 24, 2012
PubMed
Summary

Computed tomography (CT) values in blood samples can estimate time after hemorrhage. CT values change predictably over 20 days due to blood clot formation and breakdown, offering a novel dating method.

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Area of Science:

  • Medical Imaging
  • Forensic Science
  • Biochemistry

Background:

  • Estimating time since hemorrhage is crucial in clinical and forensic settings.
  • Current methods for post-hemorrhage time estimation have limitations.
  • Computed tomography (CT) offers non-invasive imaging with quantifiable Hounsfield Unit (HU) values.

Purpose of the Study:

  • To investigate the time-dependent changes in CT values of blood samples.
  • To determine if CT values can be used to estimate the elapsed time after hemorrhage.
  • To correlate CT value changes with blood coagulation and fibrinolysis processes.

Main Methods:

  • Blood samples in syringes were scanned using computed tomography (CT) over a 20-day period.
  • Average (CT(ave)) and maximum (CT(max)) CT values were measured.
  • Changes in CT values were analyzed in relation to time post-collection.

Main Results:

  • CT(ave) rapidly increased within the first 50 minutes.
  • CT(max) showed a stepwise increase, peaking at 82.4 HU after one day, then decreasing to 72.0 HU by day 20.
  • Formulas were developed to estimate time based on CT(max) changes during increasing and decreasing phases.

Conclusions:

  • The observed CT value changes correlate with fibrin generation, fibrin net formation, and fibrinolysis.
  • CT values, particularly CT(max), show potential for estimating the time elapsed since hemorrhage.
  • This study provides a basis for developing non-invasive methods for post-hemorrhage time estimation using CT imaging.