Related Experiment Video
Updated: May 20, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Venous thromboembolic disease
1Director, Vascular Medicine, Co-Director, Vascular Diagnostic Laboratory, The Heart and Vascular Institute, Morristown, NJ.
Insights
Early diagnosis and evolving treatments for venous thromboembolism (VTE) improve patient outcomes. Advances in diagnostic imaging and outpatient therapies like low-molecular-weight heparins are key to managing this potentially deadly condition effectively.
Area of Science:
- Medical Diagnostics
- Cardiovascular Medicine
- Hematology
Background:
- Venous thromboembolism (VTE) is a common, potentially fatal disorder with significant risks if undiagnosed.
- Many VTE patients present asymptomatically, complicating early detection and treatment.
- Prompt diagnosis and therapy are crucial for managing VTE and preventing severe complications.
Purpose of the Study:
- To review the evolution of diagnostic methods for VTE.
- To discuss the advancements in VTE treatment strategies.
- To highlight the impact of these changes on patient care and outcomes.
Main Methods:
- Venous duplex ultrasonography is the preferred diagnostic test for deep venous thrombosis.
- Quantitative d-dimer levels aid in diagnosing venous thrombosis.
- Helical computed tomographic scans have largely replaced ventilation-perfusion scans for pulmonary embolism diagnosis.
Main Results:
- Modern diagnostic techniques enable earlier identification of VTE.
- Treatment paradigms have shifted from inpatient intravenous heparin to outpatient subcutaneous low-molecular-weight heparins.
- Evidence-based literature supports these therapeutic advancements.
Conclusions:
- Diagnostic advancements have improved the early detection of VTE.
- Outpatient treatment with low-molecular-weight heparins represents a significant evolution in VTE management.
- These changes reflect a move towards more efficient and effective patient care for VTE.
Abstract:
Physicians understand the importance of prompt diagnosis and therapy of venous thromboembolism. This is a common and potentially deadly disease. Many patients may have no symptoms of this disorder, yet face a significant risk of serious complications if undiagnosed and untreated. Venous duplex ultrasonography has become the diagnostic test of choice for deep venous thrombosis. Quantitative d-dimer levels may be very helpful in establishing the diagnosis of venous thrombosis. Helical (spiral) computed tomographic scans have replaced nuclear medicine ventilation-perfusion imaging for pulmonary embolus. So, the evolution of diagnostic methods has helped to identify patients with venous thromboembolism at an earlier stage of the disease. Treatment of venous thromboembolism has rapidly evolved over the past 40 years. Patients are often treated with subcutaneous low-molecular-weight heparins as outpatients, rather than admitted to hospital for continuous intravenous infusions of unfractionated heparin. This change in practice grew from a body of scientific literature supporting this advance.
Related Concept Videos
Venous Thrombosis I: Introduction
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis III: Interprofessional Care
Pulmonary Embolism I: Introduction
Pulmonary Embolism I: Introduction
Venous Thrombosis IV: Nursing Management

