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Updated: May 20, 2026

Analysis and Specification of Starch Granule Size Distributions
Published on: March 4, 2021
Powder and compaction characteristics of pregelatinized starches
1Department of Pharmacy, School of Pharmaceutical Chemistry, The University of Antioquia, Medellin, Colombia. jrojasca@gmail.com
Pregelatinized starches from yucca and corn show excellent powder and tableting properties, making them potential direct compression filler-binders. Rice starch, however, is less suitable due to undesirable characteristics for direct compression.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Pregelatinized starch is a common pharmaceutical excipient, utilized as a filler-binder.
- Excipient tableting performance is influenced by its source material.
Purpose of the Study:
- To evaluate and compare the powder and tableting properties of pregelatinized starches from yucca, corn, and rice.
- To assess their suitability as direct compression filler-binders against a commercial standard (Starch 1500).
Main Methods:
- Characterization of powder properties including particle size, density, porosity, and flowability.
- Evaluation of tableting properties such as compactibility, compressibility, and disintegration.
- Comparative analysis against Starch 1500.
Main Results:
- Yucca and corn starches exhibited superior compactibility and compressibility compared to Starch 1500, with comparable plastic deformation and strain rate sensitivity.
- These starches also demonstrated slower compact disintegration than Starch 1500.
- Rice starch displayed high elasticity and friability, with low compactibility, deeming it unsuitable for direct compression.
Conclusions:
- Pregelatinized starches from yucca and corn are promising alternatives to Starch 1500 as direct compression filler-binders.
- Rice starch is not recommended for direct compression applications due to its unfavorable properties.
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