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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Visual prognosis in Behçet's disease.

H M Towler¹, S Lightman

¹Department of Clinical Science, Institute of Ophthalmology, Moorfields Eye Hospital, London, UK.

Ocular Immunology and Inflammation

|July 25, 2012

Summary

This summary is machine-generated.

Aggressive treatment improves vision in Behçet

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Area of Science:

Ophthalmology
Rheumatology
Immunology

Background:

Behçet's disease historically has a poor visual prognosis, with up to 74% vision loss.
Previous studies focused on Mediterranean populations; ethnic variations in ocular Behçet's disease progression are suggested.
Long-term effects of newer immunosuppressants like cyclosporin on visual outcomes are not well-established.

Purpose of the Study:

To evaluate the visual prognosis of patients with Behçet's disease and ocular involvement.
To assess the effectiveness of aggressive, multi-agent immunosuppressive therapy on visual outcomes.

Main Methods:

Retrospective analysis of 28 patients with ocular Behçet's disease of mixed ethnicity.
Average follow-up of six years.
Aggressive treatment of posterior segment disease relapse using corticosteroids, cyclosporin, azathioprine, cyclophosphamide, or chlorambucil.

Main Results:

Currently, 60% of patients maintain visual acuity of ± 6/9 in the better eye.
21% of patients have visual acuity between 6/12 and 6/60.
18% of patients have visual acuity worse than 6/60.

Conclusions:

Aggressive immunosuppressive therapy appears to improve visual prognosis in Behçet's disease.
Current encouraging results suggest a shift from historical poor visual outcomes.
Continued aggressive management is warranted based on these relatively short-term findings.