Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Earlier onset of Alzheimer's disease in men with Down syndrome.

Neurology·1998
Same author

Molecular prophets of death in the fly.

American journal of human genetics·1998
Same author

Is the high level of nitric oxide metabolites a marker in early rejection after experimental islet pancreas transplantation?

Transplantation proceedings·1998
Same author

Structure of the human CD94 C-type lectin gene.

Immunogenetics·1998
Same author

Risk factors, treatment, and outcome of central nervous system recurrence in adults with intermediate-grade and immunoblastic lymphoma.

Blood·1998
Same author

[Prenatal molecular genetic diagnosis and treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency].

Medicina clinica·1998
Same journal

Role of Adjunctive Intravitreal Therapy in Intraocular Tubercular Granuloma at a Tertiary Uveitis Care Centre - A Retrospective Case Series.

Ocular immunology and inflammation·2026
Same journal

Sex Differences in Uveitis Etiology: A Systematic Review and Meta-Analysis.

Ocular immunology and inflammation·2026
Same journal

Upadacitinib in Refractory Vogt-Koyanagi-Harada Disease: A Case Report.

Ocular immunology and inflammation·2026
Same journal

Choroidal and Retinal Imaging Findings in Childhood-Onset Mevalonate Kinase Deficiency: An OCT-Based Case-Control Study.

Ocular immunology and inflammation·2026
Same journal

Efficacy of infliximab therapy in the treatment of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome.

Ocular immunology and inflammation·2026
Same journal

Conjunctival Reactive Lymphoid Hyperplasia with Delayed Corneal Immune Infiltrates in the Setting of Systemic Epstein-Barr Virus Infection.

Ocular immunology and inflammation·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva
07:35

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Published on: July 5, 2017

Atopic keratoconjunctivitis.

Y A Akova1, A Rodriguez, C S Foster

  • 1Immunology & Uveitis Service, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, USA.

Ocular Immunology and Inflammation
|July 25, 2012
PubMed
Summary
This summary is machine-generated.

Atopic keratoconjunctivitis (AKC) is a severe eye condition linked to atopic dermatitis. Effective management requires environmental allergen control, antihistamines, and mast cell stabilizers for long-term vision preservation.

More Related Videos

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
08:13

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation

Published on: November 11, 2025

Related Experiment Videos

Last Updated: May 20, 2026

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva
07:35

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Published on: July 5, 2017

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
08:13

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation

Published on: November 11, 2025

Area of Science:

  • Ophthalmology
  • Allergy and Immunology
  • Dermatology

Background:

  • Atopic keratoconjunctivitis (AKC) is a chronic, bilateral eye inflammation associated with atopic dermatitis, posing a risk of vision loss.
  • AKC presents with symptoms like intense itching, burning, tearing, and mucoid discharge, alongside diverse clinical signs affecting the eyelids and cornea.
  • The disease pathogenesis involves complex immune responses, including IgE-mediated and delayed hypersensitivity reactions, driven by immunoregulatory defects.

Purpose of the Study:

  • To provide a comprehensive overview of atopic keratoconjunctivitis, encompassing its clinical spectrum, underlying mechanisms, associated conditions, and management strategies.
  • To highlight the critical role of environmental allergen control in the long-term management of AKC.
  • To emphasize the necessity of a multidisciplinary approach for controlling this sight-threatening condition.

Main Methods:

  • Review of clinical characteristics, histopathology, and immunopathophysiology of atopic keratoconjunctivitis.
  • Analysis of associated ocular conditions, such as keratoconus and herpes simplex keratitis.
  • Evaluation of current and recommended management strategies, including environmental control, pharmacotherapy, and surgical considerations.

Main Results:

  • AKC exhibits a wide range of clinical manifestations, from lid dermatitis to severe corneal complications like scarring and neovascularization.
  • Histopathology reveals characteristic inflammatory cell infiltration, including mast cells and eosinophils, in the conjunctiva.
  • Associated ocular conditions and potential vision-impairing complications underscore the severity of AKC.

Conclusions:

  • Long-term control of AKC necessitates a multidisciplinary strategy focusing on environmental allergen avoidance as the cornerstone of management.
  • Systemic antihistamines and topical mast cell stabilizers are crucial for ongoing disease control.
  • Topical corticosteroids should be used judiciously, reserved for managing acute exacerbations to minimize potential side effects.