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Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Published on: March 14, 2025

Altered cingulostriatal coupling in obsessive-compulsive disorder.

Jan Carl Beucke1, Christian Kaufmann, Clas Linnman

  • 1Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.

Brain Connectivity
|July 25, 2012
PubMed
Summary
This summary is machine-generated.

This study reveals altered brain connectivity in obsessive-compulsive disorder (OCD) patients. Specifically, abnormal communication between the anterior midcingulate cortex and ventral striatum occurs when anticipating punishment, impacting corticostriatal networks.

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06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Published on: November 27, 2019

Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Neurobiological models of obsessive-compulsive disorder (OCD) suggest corticostriatal network dysfunction.
  • Connectivity within these networks is understudied in OCD patients.
  • The anterior midcingulate cortex (aMCC) is crucial for emotion, pain, and cognitive control, and is a neurosurgical target for OCD.

Purpose of the Study:

  • To investigate altered corticostriatal coupling in OCD patients during a monetary reinforcement task.
  • To examine connectivity between the aMCC and ventral striatum when anticipating punishment.
  • To provide experimental evidence for neurobiological models of OCD.

Main Methods:

  • Utilized a monetary reinforcement paradigm.
  • Employed psychophysiological interaction (PPI) analyses.
  • Focused on the anterior midcingulate cortex (aMCC) as a seed region.

Main Results:

  • Observed significantly altered, inverse coupling between the aMCC and ventral striatum in OCD patients anticipating punishment.
  • Identified abnormal aMCC coupling with cortical areas beyond traditional corticostriatal circuitry.
  • Demonstrated direct experimental evidence of altered corticostriatal connectivity in OCD.

Conclusions:

  • Findings support the importance of connectivity methods in studying corticostriatal networks in OCD.
  • Effective connectivity methods are favored for studying OCD abnormalities during symptom provocation and reinforcement learning.
  • The identified abnormal coupling links two major neurosurgical OCD target sites.