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Updated: May 5, 2026
Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets
Published on: October 15, 2021
Design and studies of novel polyoxysterol-based porphyrin conjugates
Halina A Zhylitskaya1, Vladimir N Zhabinskii, Raisa P Litvinovskaya
1Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich str., 5/2, 220141 Minsk, Belarus.
Abstract:
New types of steroid-porphyrin conjugates derived from 20-hydroxyecdysone (20E) and 24-epibrassinolide (EBl) were synthesized. An exceptional regioselectivity in the reaction of both steroids with porphyrin boronic acids was found to give side-chain-conjugated boronic esters as sole products. UV-Vis-, fluorescence and NMR spectroscopy yielded similar data for all the studied compounds confirming the solvent driven supramolecular assembly with formation of J-aggregates. CD measurements of water diluted solutions showed a clear difference between 20E and EBl conjugates. The latter showed a strong supramolecular chirality, whereas 20E J-aggregates did not.
