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Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

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Updated: May 20, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Cholesterol and prostate cancer.

Kristine Pelton1, Michael R Freeman, Keith R Solomon

  • 1The Urological Diseases Research Center, Boston Children's Hospital, Boston, MA 02115, USA.

Current Opinion in Pharmacology
|July 25, 2012
PubMed
Summary
This summary is machine-generated.

High cholesterol levels increase the risk of aggressive prostate cancer. Cholesterol-lowering strategies may offer protective benefits, suggesting a potential new approach for prostate cancer prevention.

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Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

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Last Updated: May 20, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Published on: March 6, 2018

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

Area of Science:

  • Oncology
  • Metabolic Research
  • Environmental Health

Background:

  • Prostate cancer susceptibility is influenced by environmental factors, but underlying molecular mechanisms remain unclear.
  • Cholesterol, a steroidal lipid, is increasingly recognized as a significant factor in prostate cancer development.
  • Existing research highlights a link between cholesterol and prostate cancer risk.

Purpose of the Study:

  • To review current findings on the relationship between cholesterol and prostate cancer.
  • To explore molecular mechanisms linking cholesterol to prostate cancer risk and progression.
  • To evaluate the potential of cholesterol-lowering strategies in prostate cancer prevention.

Main Methods:

  • Systematic review of human studies, animal models, and cell biology research.
  • Analysis of epidemiological data and clinical trial outcomes.
  • Examination of experimental evidence on molecular pathways involved.

Main Results:

  • Elevated circulating cholesterol is associated with an increased risk of aggressive prostate cancer.
  • Cholesterol-lowering interventions show potential for conferring protective effects against prostate cancer.
  • Specific molecular processes mediating these effects have been identified and experimentally validated.

Conclusions:

  • Cholesterol plays a critical role in prostate cancer risk and progression.
  • Cholesterol-lowering strategies represent a promising therapeutic and preventative avenue.
  • Prospective application of these findings could reduce prostate cancer risk in specific populations.