Related Experiment Video
Updated: May 20, 2026
Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
Published on: April 2, 2021
Retinal vessel changes after laser treatment for retinopathy of prematurity
Julie Y Kwon1, Devon H Ghodasra, Karen A Karp
1Division of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. Julie.you@gmail.com
Background:
The clinical response to retinopathy of prematurity (ROP) treatment is currently assessed subjectively. This study aims to quantify treatment response objectively by assessing changes in digital images of posterior pole retinal vessel width and tortuosity.
Methods:
Images of 30 right eyes with type 1 ROP obtained at up to three time points were analyzed: before treatment (T = 0) and 1 (T = 1) and/or 2 weeks (T = 2) after treatment. Width and tortuosity of retinal vessels were analyzed from digital images using computer-assisted image analysis software.
Results:
Vessel width decreased by 20% (P < 0.004) within the first week and remained stable by the second week after laser treatment. Vessel tortuosity did not significantly change by the first week but decreased 27% (P < 0.01) by second week.
Conclusions:
Vessel width appears to decrease dramatic within the first week, whereas the regression of tortuosity follows a slower course.
