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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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Exhaled nitric oxide (FeNO) as a non-invasive marker of airway inflammation

Mitsuru Munakata1

  • 1Fukushima Medical University Hospital, Fukushima, Japan. munakata@fmu.ac.jp

Allergology International : Official Journal of the Japanese Society of Allergology
|July 25, 2012
PubMed

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...