Related Experiment Video
Updated: May 20, 2026

Conducting Respiratory Oscillometry in an Outpatient Setting
Published on: April 8, 2022
Impulse oscillometry; therapeutic impacts of transdermal long-acting Beta-2 agonist patch in elderly asthma with
Hiroshi Tanaka1, Soichiro Hozawa, Junya Kitada
1Sapporo Cough Asthma and Allergy Center, Center, South−4 West−14 Chuo-ku, Sapporo, Hokkaido, Japan. tanaka@idaimaes4−naika.com
Abstract:
Growing interest had been focused on the involvement of the small airways in asthma, and impulse oscillometry (IOS) has been utilized as pulmonary functions for detecting large and small airways diseases separately. IOS can measure respiratory resistance and reactance at multiple frequencies, not available by spirometry or body plethysmography, is non-invasive techniques and convenient for elderly patients with a low dependency on cooperation during tidal breathing. IOS indices were well correlated with not only predicted FEV1 but also FEF25-75, residual volume/total lung capacity, delta N2 of a single nitrogen washout test which representing air trapping and inhomogeneous ventilation in the distal lung. These parameters and QOL scores were improved by additional transdermal long-acting beta-2 agonist patch even in well-controlled elderly asthma treating with inhaled corticosteroids alone. IOS may have a complementary role of spirometry in detecting subtle airways changes in general practice. However, systemic studies are required to investigate the clinical implication of each IOS index.
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