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Brain isozyme of glycogen phosphorylase: immunohistological localization within the central nervous system
P C Ignacio1, B A Baldwin, V K Vijayan
1Department of Neurology, University of California, Davis 95616.
Brain Research
|October 8, 1990
Abstract:
An antibody specific for the predicted carboxyterminal sequence of the human brain isozyme of glycogen phosphorylase (alpha-1,4-D-glucan:orthophosphate D-glucosyltransferase, EC 2.4.1.1) was generated to verify the carboxyterminal amino acid sequence of this protein. The isozyme-specific antibody was used to examine the localization of this protein in primate and non-primate brain. The highest levels of the brain isozyme in cerebrum and cerebellum were found in fibrous astrocytes, many with glial processes that appear to terminate upon blood vessels.