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Updated: May 20, 2026
08:22
Measurement of Ultrafast Vibrational Coherences in Polyatomic Radical Cations with Strong-Field Adiabatic Ionization
Published on: August 6, 2018
Single-fiber diffuse optical time-of-flight spectroscopy
Erik Alerstam1, Tomas Svensson, Stefan Andersson-Engels
1Department of Physics, Lund University, P.O. Box 118, 221 00 Lund, Sweden. erik.alerstam@fysik.lth.se
Optics Letters
|July 25, 2012
Summary
This study introduces a novel single-fiber diffuse optical spectroscopy technique. It accurately measures tissue absorption independently of scattering, enabling simpler, less invasive in vivo measurements.
Area of Science:
- Biomedical Optics
- Spectroscopy
- Medical Physics
Background:
- Interstitial diffuse optical spectroscopy offers potential for in vivo tissue analysis.
- Current methods face challenges with scattering, absorption, and complex instrumentation.
Purpose of the Study:
- To develop and validate a simplified interstitial diffuse optical time-of-flight spectroscopy system.
- To demonstrate the independent assessment of tissue absorption and scattering properties.
Main Methods:
- Utilized a single fiber for both light delivery and detection.
- Employed ultrafast gating of a single photon avalanche diode to prevent detector saturation.
- Performed measurements on calibrated liquid phantoms.
- Conducted Monte Carlo-based evaluation for data analysis.
Main Results:
- Successfully separated scattering and absorption effects in optical measurements.
- Demonstrated accurate assessment of absorption coefficients independent of scattering.
- Validated the technique across a range of medically relevant optical properties.
Conclusions:
- The developed single-fiber spectroscopy system simplifies interstitial optical measurements.
- This technique enables accurate, independent assessment of tissue absorption in vivo.
- Paves the way for less invasive spectroscopic diagnostics.
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