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Preoperative localization strategies for primary hyperparathyroidism: an economic analysis

Carrie C Lubitz1, Antonia E Stephen, Richard A Hodin

  • 1Endocrine Surgery Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. clubitz@partners.org

Annals of Surgical Oncology
|July 25, 2012
PubMed
Summary

Ultrasound (US) followed by 4D-CT is the most cost-effective strategy for localizing parathyroid pathology. This approach offers significant savings compared to other methods, including sestamibi and bilateral neck exploration.

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The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...