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The effects of vitamin D deficiency on atrial fibrillation

Mehmet Demir1, Umut Uyan, Mehmet Melek

  • 11Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|July 25, 2012
PubMed

Insights

Vitamin D deficiency is linked to nonvalvular atrial fibrillation (AF). Patients with nonvalvular AF had lower vitamin D levels compared to those with valvular AF or healthy controls.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is a known risk factor for cardiovascular diseases, including hypertension and heart failure.
  • Vitamin D deficiency may influence the renin-angiotensin-aldosterone system, potentially impacting cardiovascular health.
  • A potential link between vitamin D deficiency and atrial fibrillation (AF) warrants investigation.

Purpose of the Study:

  • To investigate the association between vitamin D levels and different types of atrial fibrillation (AF).
  • To compare 25-hydroxyvitamin D (25-OHD) levels in patients with nonvalvular AF, valvular AF, and healthy controls.

Main Methods:

  • A comparative study involving 102 patients with nonvalvular AF (Group I) and 96 with valvular AF (Group II).
  • 100 age-matched healthy individuals in sinus rhythm served as the control group.
  • Measurement of routine biochemical parameters, 25-hydroxyvitamin D (25-OHD), and parathormone levels.

Main Results:

  • Patients with nonvalvular AF (Group I) exhibited significantly lower vitamin D levels (6.51 ± 4.89 ng/mL) compared to valvular AF (Group II) (9.24 ± 7.39 ng/mL) and controls (11.18 ± 6.98 ng/mL).
  • Left atrium diameter and systolic pulmonary artery pressure were elevated in both nonvalvular and valvular AF groups compared to controls.

Conclusions:

  • The study demonstrates a significant relationship between vitamin D deficiency and nonvalvular atrial fibrillation.
  • These findings suggest vitamin D status may play a role in the pathophysiology of nonvalvular AF.
Abstract

Keywords:
arrhythmiaatrial fibrillationrenin–angiotensin–aldosterone systemvitamin D

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