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Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study
Ayşegül Ülgen Kunak1, Tolga Kunak2, Ertan Aydın3
1Department of Cardiology, Antalya Training and Research Hospital, University of Health Sciences, Antalya 07100, Türkiye.
Journal of Clinical Medicine
|August 13, 2026
Summary
Benidipine effectively lowers blood pressure and improves angina-related health status in patients with hypertension or chronic coronary syndrome. However, the link between blood pressure reduction and symptom improvement is weak, suggesting other factors influence patient outcomes.
Area of Science:
- Cardiology
- Pharmacology
- Health Outcomes Research
Background:
- Benidipine is a long-acting calcium channel blocker for hypertension and chronic coronary syndrome.
- The relationship between benidipine's blood pressure reduction and angina symptom improvement is not well-established.
- Real-world data on benidipine's impact on both blood pressure and patient-reported health status is needed.
Purpose of the Study:
- To evaluate the changes in blood pressure and angina-related health status in a large real-world cohort of patients treated with benidipine.
- To identify predictors of blood pressure reduction and symptomatic improvement.
- To explore differences in treatment response based on coronary artery disease status.
Main Methods:
- Prospective, multicenter, observational cohort study of 1659 patients with hypertension and/or chronic coronary syndrome.
- Assessment of systolic and diastolic blood pressure and Seattle Angina Questionnaire-7 (SAQ-7) scores at baseline and after 3 months.
- Multivariable linear regression and propensity score-matched analyses were used to evaluate outcomes.
Main Results:
- Benidipine therapy significantly reduced systolic blood pressure by 13.8 mmHg and diastolic blood pressure by 6.7 mmHg (p < 0.001).
- Mean SAQ-7 scores improved by 8.1 points (p < 0.001), indicating a clinically meaningful enhancement in angina-related health status.
- A weak correlation (r = 0.058, p = 0.023) was observed between changes in blood pressure and SAQ-7 scores, with baseline SAQ-7 and systolic blood pressure being the strongest predictors of their respective changes.
Conclusions:
- Benidipine therapy in a real-world setting leads to significant blood pressure reduction and clinically meaningful improvements in angina-related health status.
- Symptomatic improvement during benidipine treatment is weakly associated with the degree of blood pressure reduction.
- Further controlled studies are warranted to confirm these findings and elucidate the mechanisms of symptomatic improvement.
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