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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Nano-organized shells and their application in controlled release.

Ming-Wei Chang1, Eleanor Stride, Mohan Edirisinghe

  • 1Department of Mechanical Engineering, University College London, Torrington Place, London WCIE 7JE, UK.

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|July 25, 2012
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Summary

Controlling hollow-shell drug-carrier shell thickness and structure via electrohydrodynamic processing allows for tailored liquid release. Thicker shells with consistent nanopores reduce release rates, enabling precise drug delivery applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Drug delivery carrier performance hinges on shell properties like thickness and porosity.
  • Understanding these relationships is crucial for optimizing drug release profiles.

Purpose of the Study:

  • To investigate how electrohydrodynamic processing parameters influence hollow-shell drug-carrier properties.
  • To correlate shell characteristics (thickness, nanopores) with the release rate of encapsulated liquids.

Main Methods:

  • Hollow spherical polymer capsules were fabricated using electrohydrodynamic processing with varying shell thicknesses (100-150 nm).
  • Shell nanopore size and structure were analyzed via electron microscopy.
  • Release profiles of a water-soluble dye were measured using ultraviolet spectroscopy.

Main Results:

  • Nanopore diameter remained consistent (~5 nm) across different shell thicknesses, with radial alignment.
  • Increased shell thickness led to a decreased and more linear release rate over time.
  • Diffusion was confirmed as the dominant release mechanism.

Conclusions:

  • Electrohydrodynamic processing enables precise control over nanoscale shell structures in drug carriers.
  • Tailoring shell thickness and nanopore characteristics allows for predictable modulation of drug release kinetics.