Related Experiment Video

Updated: May 20, 2026

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

Coronary artery dilation among patients with paediatric-onset systemic lupus erythematosus

C C Shen1, H T Chung, Y L Huang

  • 1Division of Allergy, Asthma, and Rheumatology, Department of Paediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Scandinavian Journal of Rheumatology
|July 26, 2012
PubMed

Insights

Children with childhood-onset systemic lupus erythematosus (SLE) have larger coronary arteries. Higher serum uric acid (UA) levels, earlier age at diagnosis, and increased body mass index (BMI) are linked to these enlarged arteries.

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Pediatrics

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organ systems.
  • Cardiovascular complications, including coronary artery disease (CAD), are a significant concern in patients with SLE.
  • Paediatric-onset SLE may have unique risk factors and disease trajectories compared to adult-onset SLE.

Purpose of the Study:

  • To compare coronary artery dimensions in children with SLE versus healthy controls.
  • To identify risk factors associated with increased coronary artery dimensions in paediatric SLE patients.

Main Methods:

  • Cross-sectional analysis of 83 children with SLE and 36 healthy controls.
  • Echocardiographic measurement of coronary artery diameters.
  • Assessment of body mass index (BMI), blood pressure, serum uric acid (UA), creatinine, and lupus-related factors.

Main Results:

  • Significantly larger body surface area (BSA)-adjusted left and right coronary artery dimensions were observed in SLE patients compared to controls (p < 0.001).
  • Age at diagnosis, BMI, and serum UA and creatinine levels were associated with coronary artery diameters.
  • Multivariate analysis confirmed serum UA level, age at diagnosis, and BMI as consistent predictors of coronary artery dimensions (p < 0.05 for all).

Conclusions:

  • Children with paediatric-onset SLE exhibit increased coronary artery dimensions.
  • Elevated serum uric acid levels are a key risk factor associated with these enlarged coronary arteries in paediatric SLE.
  • Further research is needed to elucidate the underlying pathogenic mechanisms.
Abstract

More Related Videos

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...