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Published on: December 17, 2021
Calprotectin is raised in endogenous posterior uveitis
J A Olson1, M Forrester, P A Clohessy
1Departments of Ophthalmology, Child Health and Pathology, University of Aberdeen, Medical School, Foresterhill, Aberdeen, AB9 2ZD, Scotland UK.
Ocular Immunology and Inflammation
|July 26, 2012
Summary
Plasma calprotectin levels are elevated in active endogenous posterior uveitis (EPU). This suggests calprotectin may serve as a sensitive biomarker for monitoring EPU disease activity.
Area of Science:
- Immunology
- Ophthalmology
Background:
- Calprotectin, a leucocyte protein, is abundant in granulocytes and monocytes.
- Elevated plasma calprotectin is linked to various pathological conditions including infections and tumors.
Purpose of the Study:
- To investigate plasma calprotectin and ANCA levels in patients with endogenous posterior uveitis (EPU).
- To assess the correlation between calprotectin, ANCA, and EPU disease activity.
Main Methods:
- Plasma calprotectin and ANCA levels were measured in 27 EPU patients and 6 healthy controls.
- Statistical analysis, including ANOVA, was used to compare groups.
Main Results:
- Mean plasma calprotectin levels were significantly higher in active EPU patients compared to controls (p<0.005).
- Elevated serum ANCA titres were observed in some EPU patients, but did not correlate with calprotectin levels.
Conclusions:
- Plasma calprotectin levels are increased in active endogenous posterior uveitis.
- Plasma calprotectin measurement may be a sensitive indicator of disease activity in EPU.
