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Updated: May 20, 2026

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Gold-catalyzed hydrosilyloxylation driving tandem aldol and Mannich reactions
Dongjin Kang1, Sangjune Park, Taekyu Ryu
1Department of Chemistry, Kangwon National University, Chuncheon 200-701, Republic of Korea.
Abstract:
The chemoselective formation of an enolate from alkyne in the presence of a carbonyl and imine group was realized, which constructed a variety of structural motifs under exceedingly mild reaction conditions in a tandem process. Reaction driving tandem hydrosilyloxylation/aldol reactions was achieved through the formation of enol silyl ethers catalytically generated in situ from readily available alkynes. These reactions were expanded to obtain β-amino enol silyl ethers in good yields via the tandem hydrosilyloxylation/isomerization/Mannich reaction.
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