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Topical therapies for periorbital cutaneous malignancies: indications and treatment regimens

Timothy J Sullivan1

  • 1Eyelid, Lacrimal and Orbital Clinic, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. tjs001@bigpond.net.au

Current Opinion in Ophthalmology
|July 26, 2012
PubMed
Abstract

Insights

Topical treatments show promise for periorbital skin cancers. Established agents like 5-fluorouracil and imiquimod are effective, while newer options require further research for managing skin tumors around the eyes.

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Periorbital skin cancers, including melanoma and nonmelanoma types, pose unique management challenges.
  • Understanding the pathogenesis of these tumors is crucial for developing targeted therapies.

Purpose of the Study:

  • To review periorbital cutaneous tumorogenesis.
  • To identify stages amenable to topical treatments.
  • To discuss the efficacy of topical agents in managing periorbital skin malignancies.

Main Methods:

  • Literature review of studies on periorbital tumorogenesis.
  • Analysis of research on topical agents for skin cancer treatment.
  • Evaluation of clinical data on the use of 5-fluorouracil, imiquimod, ingenol mebutate, tazarotene, and diclofenac gel.

Main Results:

  • Advances in understanding skin cancer pathogenesis have led to targeted topical agents.
  • Topical therapies have demonstrated effectiveness in treating periorbital skin cancers.
  • Established agents like 5-fluorouracil and imiquimod are key players.

Conclusions:

  • 5-Fluorouracil and imiquimod are proven treatments for periorbital skin malignancies.
  • Emerging agents like ingenol mebutate, tazarotene, and diclofenac gel show potential but need more research.
  • Topical treatments offer a promising avenue for managing skin tumors in the periorbital region.

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