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Dynamics of major histocompatibility complex class I association with the human peptide-loading complex

Michaela S Panter1, Ankur Jain, Ralf M Leonhardt

  • 1Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.

The Journal of Biological Chemistry
|July 26, 2012
PubMed
Summary

The human peptide-loading complex (PLC) composition varies, with a critical TAP/tapasin ratio of 1:2. Its MHC I association dynamically adapts to peptide availability, crucial for antigen presentation.

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