[Prognostic significance of nucleolar markers in chronic lymphocytic leukemia]

The morphological criteria have been identified permitting the prognosis of the course character of chronic lymphoid leukemia (CLL). Slow progressing of CLL is attended by the accumulation in the peripheral blood of lymphocytes in the transient stage G0----G1 with ring-like nucleoli surrounded by the perinuclear area. In rapid progressing of the disease, lymphoid cells in stages G1 and S with homogenous nucleoli containing the nucleolar lipid component, are observed in the blood of CLL patients.