Comparing subcutaneous fluid infusion with intravenous fluid infusion in children

Laura L Kuensting1

  • 1Mercy Children’s Hospital, St. Louis, MO 63129, USA. laura@kuensting.net

Insights

Subcutaneous (SC) infusions offer a faster way to start parenteral rehydration in children with mild to moderate illness, significantly reducing the number of needlesticks compared to intravenous (IV) methods.

Area of Science:

  • Pediatrics
  • Emergency Medicine
  • Fluid Management

Background:

  • Subcutaneous (SC) infusion is explored as a parenteral alternative for pediatric patients with mild to moderate illness.
  • Intravenous (IV) fluid administration is the standard, but can present challenges in pediatric care.

Purpose of the Study:

  • Compare infusion start times between initial SC and IV fluid orders.
  • Evaluate the number of needlesticks required for each method.
  • Determine if SC fluids improve subsequent IV cannulation success.

Main Methods:

  • Retrospective descriptive study of 36 children's medical records (November 2008 - May 2010).
  • Included children receiving SC fluids only or SC fluids after multiple failed IV attempts.

Main Results:

  • The SC group had a significantly shorter time to infusion (20.95 minutes) compared to the IV/SC group (97.33 minutes).
  • The SC group required fewer needlesticks (mean = 1) than the IV/SC group (mean = 4.87).

Conclusions:

  • SC infusions appear to facilitate parenteral rehydration initiation in non-critically ill children.
  • SC infusions significantly minimize patient discomfort by reducing needlesticks.
  • Further research is needed to confirm if SC fluids enhance subsequent IV cannulation success.
Abstract

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
IV Infusion to Oral Dosing: Conversion Methods01:28

IV Infusion to Oral Dosing: Conversion Methods

The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...