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Updated: May 20, 2026
09:57
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
Published on: January 11, 2020
Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures
Patrick J Riss1, Valentina Ferrari, Laurent Brichard
1The Wolfson Brain Imaging Centre, Box 65 Addenbrooke's Hospital, CB2 0QQ, Cambridge, United Kingdom. pr340@wbic.cam.ac.uk
Organic & Biomolecular Chemistry
|July 27, 2012
Abstract:
A rapid and efficient protocol to afford the title compound 2-[(18)F]-fluoro-2,2-difluoroethyl tosylate ([(18)F]7b) is described. Starting from [(18)F]fluoride ion, labelling reagent 7b was obtained in good yields and a high specific radioactivity. Compound ([(18)F]7b) was then used to synthesise a prospective radiotracer for PET-imaging in dementia.
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