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Application of thermospray liquid chromatography-mass spectrometry for the analysis of chloramphenicol and three
W A Korfmacher1, T A Getek, E B Hansen
1U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Journal of Chromatographic Science
|May 1, 1990
Abstract:
The thermospray (TS) liquid chromatographic-mass spectrometric analysis of the antibiotic chloramphenicol and three related compounds is presented. The three additional compounds are dehydrochloramphenicol, aminodehydrochloramphenicol, and nitrophenylaminopropanediol. Baseline separation of the four compounds is achieved. The TS mass spectrum of each of the four compounds includes a prominent [MH]+ ion plus some fragment ion peaks.