Related Experiment Video
Updated: May 20, 2026
09:50
Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications
Published on: December 22, 2023
Curdlan complexes as a potential food-grade delivery system: genistein case study.
Ramanathan Lakshminarayanan1, Ellina Kesselman, Revital Cohen
1Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India.
Therapeutic Delivery
|July 27, 2012
Summary
New curdlan-genistein complexes offer enhanced genistein delivery. These complexes protect genistein and provide slow release, with potential for digestive tract applications.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Chemical Engineering
Background:
- Genistein is a valuable isoflavone with therapeutic potential.
- Curdlan, a polysaccharide, can be utilized for controlled release applications.
- Developing effective delivery systems for genistein is crucial for its therapeutic efficacy.
Purpose of the Study:
- To prepare and characterize complexes of curdlan and genistein using different methods.
- To investigate the structural changes and genistein loading in curdlan-genistein complexes.
- To evaluate the release kinetics of genistein from the prepared complexes.
Main Methods:
- Complexation of curdlan and genistein under varied conditions (temperature, solvent).
- Characterization using X-ray diffraction, particle size analysis, atomic force microscopy, and scanning electron microscopy.
- In vitro release studies, including assessment of enzymatic digestion effects.
Main Results:
- Curdlan-genistein complexes prepared at 40°C showed the highest genistein content (2.3 mg/100 mg).
- Complexation altered the crystalline structure of curdlan and genistein, forming new nanoscale structures.
- All complexes demonstrated prolonged genistein release up to 72 hours, enhanced by enzymatic digestion.
Conclusions:
- Curdlan-genistein complexes can be effectively prepared with varying genistein loading.
- The complexes exhibit unique structural properties at the nanoscale, indicating molecular interaction.
- These complexes show potential as a delivery system for the protection and controlled release of genistein in the digestive tract.
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:27Drug Delivery Systems: Different Types
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
01:23Oral Drug Delivery Systems: Introduction
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
01:19Modified-Release Drug Delivery Systems: Overview
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...