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Lung function measurement with multiple-breath-helium washout system.

J-Y Wang¹, M E Suddards, C J Mellor

¹School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD, UK. jauyi.wang@nottingham.ac.uk

Medical Engineering & Physics

|July 28, 2012

Summary

Helium washout tests offer a more sensitive method for detecting lung ventilation inhomogeneity, especially in small airways. This study found mild asthmatics exhibit greater inhomogeneity, and smokers may show early signs.

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Area of Science:

Pulmonary Physiology
Respiratory Medicine
Medical Instrumentation

Background:

Multiple-breath-washout (MBW) is a sensitive technique for assessing ventilation inhomogeneity.
Conventional MBW uses nitrogen washout (MBNW).
Smaller, less dense tracer gases may improve sensitivity to small airway inhomogeneity.

Purpose of the Study:

To investigate helium as a tracer gas for multiple-breath washout (MBHW).
To assess the sensitivity of MBHW to ventilation inhomogeneity in small airways.
To present a novel MBHW system utilizing quartz tuning forks.

Main Methods:

Developed and utilized a multiple-breath-helium-washout (MBHW) system.
Employed quartz tuning forks to detect respiratory gas density changes.
Determined helium concentration using CO2 measurements from an infrared detector.

Main Results:

MBHW system successfully measured ventilation inhomogeneity.
Mild asthmatics demonstrated significantly higher ventilation inhomogeneity.
A distinct washout curve feature in smokers suggested early acinar airway inhomogeneity.

Conclusions:

Helium washout is a promising, sensitive method for detecting lung ventilation inhomogeneity, particularly in small airways.
MBHW can identify inhomogeneity in mild asthmatics and potential early changes in smokers.
The developed MBHW system provides a valuable tool for lung function studies.