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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

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Related Experiment Video

Updated: May 20, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

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Published on: June 3, 2018

Risk factors for visual field progression in the low-pressure glaucoma treatment study.

Carlos Gustavo De Moraes1, Jeffrey M Liebmann, David S Greenfield

  • 1Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, USA. demoraesmd@gmail.com

American Journal of Ophthalmology
|July 28, 2012
PubMed
Summary

Brimonidine tartrate 0.2% showed a protective effect against visual field progression in low-pressure glaucoma compared to timolol maleate 0.5%. Lower ocular perfusion pressure, older age, and antihypertensive use were identified as risk factors for progression.

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Published on: April 24, 2020

Area of Science:

  • Ophthalmology
  • Clinical Trials
  • Glaucoma Research

Background:

  • Low-pressure glaucoma (LPG) presents a diagnostic and therapeutic challenge.
  • Visual field progression is a key indicator of glaucoma severity and treatment efficacy.
  • The Low-pressure Glaucoma Treatment Study (LoGTS) aimed to evaluate treatment effects on visual function.

Purpose of the Study:

  • To identify risk factors associated with visual field progression in patients with low-pressure glaucoma.
  • To compare the efficacy of brimonidine tartrate 0.2% versus timolol maleate 0.5% in preventing visual field progression.
  • To analyze ocular and systemic factors influencing glaucoma progression.

Main Methods:

  • A prospective cohort study design was employed within the LoGTS.
  • Patients with at least 5 visual field tests were included.
  • Visual field progression was defined by pointwise linear regression analysis, and risk factors were analyzed using Cox proportional hazards models.

Main Results:

  • Eyes randomized to timolol maleate showed faster visual field progression than those randomized to brimonidine tartrate.
  • Older age, use of systemic antihypertensives, and lower mean ocular perfusion pressure were significantly associated with increased risk of progression.
  • Randomization to brimonidine demonstrated a protective effect against visual field progression.

Conclusions:

  • Brimonidine tartrate 0.2% offered a protective benefit against visual field progression compared to timolol maleate 0.5% in LPG.
  • Lower mean ocular perfusion pressure emerged as a significant risk factor for progression, independent of treatment allocation.
  • Further research is warranted due to a high dropout rate in the brimonidine arm and potential implications for clinical practice.