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Related Concept Videos

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone
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Published on: May 10, 2019

Expression pattern of Sox2 during mouse tooth development.

Li Zhang1, Guohua Yuan, Huan Liu

  • 1State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.

Gene Expression Patterns : GEP
|July 28, 2012
PubMed
Summary
This summary is machine-generated.

The transcription factor Sox2 is crucial for tooth development in mice, particularly in maintaining the pluripotency of stem cells in incisors and molars. Its expression patterns suggest a key role in odontogenesis.

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Oral Biology

Background:

  • Sox2 is a transcription factor vital for maintaining pluripotency in embryonic stem cells and adult progenitors.
  • The role of Sox2 in odontogenesis (tooth development) has not been previously reported.

Purpose of the Study:

  • To investigate the expression patterns of Sox2 during mouse incisor and molar development.
  • To determine the potential involvement of Sox2 in odontogenesis and stem cell maintenance during tooth formation.

Main Methods:

  • Real-time PCR to quantify Sox2 mRNA levels.
  • In situ hybridization to visualize Sox2 mRNA distribution.
  • Immunohistochemistry to detect Sox2 protein localization.

Main Results:

  • Sox2 mRNA and protein were detected in dental epithelium and mesenchyme during mouse tooth development.
  • Sox2 expression was prominent in the labial cervical loop of incisors and showed asymmetrical distribution in molars.
  • Expression was observed in Hertwig's epithelial root sheath cells and dental pulp perivascular regions in later stages.

Conclusions:

  • Sox2 plays a significant role in mouse odontogenesis.
  • Sox2 likely participates in maintaining the pluripotency of epithelial stem cells in developing incisors and molars.
  • Sox2 regulation during tooth development may occur at the post-transcriptional level.