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Leveraging models of cell regulation and GWAS data in integrative network-based association studies

Andrea Califano1, Atul J Butte, Stephen Friend

  • 1Columbia Initiative in Systems Biology, Columbia University, New York, New York, USA. califano@c2b2.columbia.edu

Nature Genetics
|July 28, 2012
PubMed
Abstract

No abstract available in PubMed .

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...