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Published on: December 9, 2022

Evaluation of fibronectin and C-reactive protein levels in patients with sepsis: a case-control study

Mojgan Mamani1, Seyyed Hamid Hashemi, Mehrdad Hajilooi

  • 1Department of Infectious Diseases, Hamedan University of Medical Sciences, Hamedan, Iran.

Acta Medica Iranica
|July 28, 2012
PubMed

Insights

Sepsis diagnosis can be improved by measuring plasma levels of fibronectin and C-reactive protein (CRP). Elevated CRP and decreased fibronectin show potential as reliable sepsis biomarkers.

Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Infectious Diseases

Background:

  • Sepsis affects 750,000 Americans annually and is a leading cause of death.
  • Improved diagnosis and management of sepsis are urgently needed.
  • Current diagnostic methods require enhancement for timely intervention.

Purpose of the Study:

  • To evaluate plasma levels of fibronectin and C-reactive protein (CRP) in sepsis patients.
  • To compare these levels with patients having other infectious diseases without sepsis.
  • To identify potential biomarkers for sepsis diagnosis.

Main Methods:

  • A case-control study involving 90 sepsis patients and 90 non-septic infectious disease patients.
  • Measurement of serum fibronectin and CRP levels.
  • Statistical analysis using SPSS version 15.

Main Results:

  • Mean fibronectin levels were lower in sepsis patients (288.97±89.10 mg/l) compared to controls (341.24±110.53 mg/l), P=0.001.
  • Mean CRP levels were significantly higher in sepsis patients (89.42±54.05 µg/ml) versus controls (27.42±25.89 µg/ml), P<0.001.
  • Elevated CRP was noted in septic patients with urinary tract infection, pneumonia, and soft tissue infections.

Conclusions:

  • Decreased fibronectin and increased CRP plasma levels may serve as reliable diagnostic markers for sepsis.
  • C-reactive protein (CRP) shows potential as a superior predictive factor for sepsis compared to fibronectin.
  • Further research can validate these findings for clinical application.

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