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Malignant lymphoma of the rectum
Japanese Journal of Clinical Oncology
|December 1, 1990
Summary
Primary rectal lymphoma often presents as intermediate lymphocytic lymphoma (ILL) and is frequently associated with reactive lymphoid hyperplasia (RLH). This suggests chronic inflammation may play a role in its development, similar to other lymphomas.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Primary lymphoma of the rectum is a rare condition.
- Reactive lymphoid hyperplasia (RLH) is a non-neoplastic condition that can mimic lymphoma.
- Understanding the relationship between RLH and rectal lymphoma is crucial for accurate diagnosis and treatment.
Purpose of the Study:
- To review cases of primary rectal lymphoma.
- To investigate the association between rectal lymphoma and RLH.
- To characterize the immunophenotype and genetic features of rectal lymphomas.
Main Methods:
- Histological review of eleven primary rectal lymphoma cases.
- Immunohistochemistry on paraffin-embedded sections.
- Gene rearrangement study for clonality assessment.
Main Results:
- Six cases were classified as intermediate lymphocytic lymphoma (ILL).
- RLH was found in all ILL cases and three other cases.
- Eight cases were B-cell type, one T-cell type, and one morphologically B-cell type.
Conclusions:
- Rectal lymphoma is characterized by a high frequency of ILL and association with RLH.
- Long-standing inflammation may be an etiologic factor in rectal lymphoma.
- Findings suggest a common etiology for lymphomas in the rectum, thyroid, salivary glands, and stomach.