Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Overcoming Challenges and Ensuring Effective Implementation of the Family Adoption Program: An Administrator's Commentary.

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine·2026

Same author

Characteristics of Fall among Older People in Rural Puducherry.

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine·2019

Same author

Dapsone Induced Methaemoglobinemia.

Indian journal of dermatology, venereology and leprology·2017

Same author

Xeroderma Pigmentosum with Mailgnant Melanoma and Squamous Cell Carcinoma.

Indian journal of dermatology, venereology and leprology·2017

Same author

Kyrle's Disease with Diabetes Meuxfus and Chronic Renal Failure.

Indian journal of dermatology, venereology and leprology·2017

Same author

Annular elastolytic giant cell granuloma in association with Hashimoto's thyroiditis.

Indian dermatology online journal·2016

Search research articles

Related Experiment Video

Updated: May 20, 2026

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

In-transit metastases from squamous cell carcinoma penis.

L Padmavathy¹, L Lakshmana Rao, Sylvester

¹Division of Community Medicine, RMMC, Annamalai University, Annamalai Nagar, Tamil Nadu, India. padmavathy.lanka@gmail.com

Indian Journal of Dermatology

|July 28, 2012

Summary

This case report details an unusual instance of in-transit metastases in a patient with penile cancer. The findings highlight the importance of recognizing rare metastatic patterns in oncology.

Keywords:

In-transit metastasis inguinal lymph nodes penis squamous cell carcinoma

More Related Videos

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

Related Experiment Videos

Last Updated: May 20, 2026

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

Area of Science:

Oncology
Surgical Pathology
Medical Oncology

Background:

In-transit metastasis is defined as tumor spread to lymphatic channels between the primary tumor and regional lymph nodes.
Penile squamous cell carcinoma can metastasize to regional lymph nodes.
Cutaneous metastases can occur in various cancers, but in-transit presentation is less common.

Purpose of the Study:

To report an uncommon case of in-transit penile cancer metastasis.
To discuss the clinical presentation and implications of this rare metastatic pattern.

Main Methods:

Case report of a 65-year-old male patient.
Review of patient's medical history including partial penile amputation and lymph node resection.
Clinical examination and documentation of metastatic lesions.

Main Results:

The patient presented with multiple cutaneous metastatic lesions in the pubic region and scrotum.
These lesions were located between the primary tumor site and the resected lymph node basin.
This presentation is consistent with in-transit metastases.

Conclusions:

In-transit metastases represent a distinct pattern of cancer spread.
This case underscores the variability in penile cancer metastasis.
Awareness of such uncommon presentations is crucial for accurate diagnosis and management.