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Multicentric reticulohistiocytosis: a rare case report
Soumya Mukherjee1, Dwijendra N Gangopadhyay
1Department of Pathology, Burdwan Medical College, Burdwan, India. doctormukherjee80@gmail.com
Indian Journal of Dermatology
|July 28, 2012
Summary
Multicentric reticulohistiocytosis is a rare disorder characterized by joint pain and skin lesions. Histopathology confirmed the diagnosis in a patient presenting with polyarthritis and characteristic skin findings.
Area of Science:
- Dermatology
- Rheumatology
- Pathology
Background:
- Multicentric reticulohistiocytosis (MRH) is a rare, non-Langerhans cell histiocytosis.
- It typically presents with arthritis and characteristic skin and/or mucosal lesions.
Purpose of the Study:
- To describe a case of multicentric reticulohistiocytosis presenting with polyarthritis and specific dermatological findings.
- To highlight the diagnostic role of histopathology in confirming MRH.
Main Methods:
- Clinical presentation review including dermatological examination and joint assessment.
- Histopathological analysis of skin biopsy specimens.
Main Results:
- The patient exhibited polyarthritis and multiple shiny, erythematous, dome-shaped papulonodules on the face and around joints.
- The characteristic 'coral bead' sign was observed on the fingers.
- Histopathology revealed a dermal infiltrate of multinucleated giant cells and macrophages with eosinophilic cytoplasm, confirming MRH.
Conclusions:
- Multicentric reticulohistiocytosis can present with prominent polyarthritis and distinctive skin manifestations.
- Histopathological examination is crucial for the definitive diagnosis of this rare condition.
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