Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Extent Of Gender/Sex Variables Included In Clinical Algorithms Across Medical Specialties.

Health affairs (Project Hope)·2026

Same author

Declarations of Independence - Physicians and the U.S. Body Politic, 1776-2026.

The New England journal of medicine·2026

Same author

Prescription without Precision - Dangers of Dosing on the Basis of Race as Biology.

The New England journal of medicine·2026

Same author

Carbon Dots and Their Functionalization with Photosensitizer Chlorin E6: Advancing Antibacterial Efficacy Through Enhanced Photodynamic Effects.

Pharmaceutics·2026

Same author

A Eulogy for Structural Competence?

The New England journal of medicine·2026

Same author

The Rise, Fall, and Laser Resurrection of the "Snake Heart" Operation.

Journal of the history of medicine and allied sciences·2026

Search research articles

Related Experiment Video

Updated: May 20, 2026

Film Extrusion of Crambe abyssinica/Wheat Gluten Blends

Film Extrusion of Crambe abyssinica/Wheat Gluten Blends

Published on: January 17, 2017

Hot-melt extrusion technology and pharmaceutical application.

Matthew Wilson¹, Marcia A Williams, David S Jones

¹Queen's University Belfast, School of Pharmacy, 97 Lisburn Road, Belfast BT9 7BL, UK. mwilson21@qub.ac.uk

Therapeutic Delivery

|July 31, 2012

Summary

This summary is machine-generated.

Hot-melt extrusion (HME) enhances drug solubility and bioavailability by molecularly dispersing poorly soluble drugs in a polymer carrier. This pharmaceutical manufacturing technique is crucial for developing advanced drug-delivery systems.

More Related Videos

Study of a Dot-patterning Process on Flexible Materials using Impact Print-Type Hot Embossing Technology

Study of a Dot-patterning Process on Flexible Materials using Impact Print-Type Hot Embossing Technology

Published on: April 6, 2020

Twin-Screw Extrusion Process to Produce Renewable Fiberboards

Twin-Screw Extrusion Process to Produce Renewable Fiberboards

Published on: January 27, 2021

Related Experiment Videos

Last Updated: May 20, 2026

Film Extrusion of Crambe abyssinica/Wheat Gluten Blends

Film Extrusion of Crambe abyssinica/Wheat Gluten Blends

Published on: January 17, 2017

Study of a Dot-patterning Process on Flexible Materials using Impact Print-Type Hot Embossing Technology

Study of a Dot-patterning Process on Flexible Materials using Impact Print-Type Hot Embossing Technology

Published on: April 6, 2020

Twin-Screw Extrusion Process to Produce Renewable Fiberboards

Twin-Screw Extrusion Process to Produce Renewable Fiberboards

Published on: January 27, 2021

Area of Science:

Pharmaceutical Technology
Materials Science
Drug Delivery

Background:

Hot-melt extrusion (HME) is a widely adopted manufacturing process with a long history in the plastics and medical device industries.
Its application in pharmaceuticals is growing, driven by the need to improve the solubility and bioavailability of novel drug compounds.
HME is particularly effective for creating advanced drug-delivery systems, including solid dosage forms and transdermal patches.

Purpose of the Study:

To highlight the increasing significance of hot-melt extrusion (HME) in pharmaceutical manufacturing.
To explain the mechanism of HME in improving drug solubility and bioavailability.
To address the challenges and advancements in HME for drug-delivery systems.

Main Methods:

HME utilizes heat, pressure, and agitation within an extrusion channel to mix and process materials.
Twin-screw extruders are commonly employed for solid dosage forms, providing both dispersive and distributive mixing with high shear.
The process disperses drug particles within a polymer matrix, achieving molecular dispersion.

Main Results:

HME facilitates the molecular dispersion of poorly soluble drugs within polymer carriers.
This dispersion significantly enhances drug dissolution rates and improves overall bioavailability.
A key challenge is stabilizing amorphous drugs to prevent recrystallization during storage.

Conclusions:

Hot-melt extrusion is a vital process for enhancing drug solubility and creating effective solid dispersions.
The pharmaceutical industry is seeing increased development of specialized HME equipment and materials.
HME offers a significant pathway for the development of advanced pharmaceutical formulations and drug-delivery systems.