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Informing the dosing of interventions in randomized trials
Corrine I Voils1, Yunkyung Chang, Jamie Crandell
1Durham VA Medical Center, Durham, NC 27705, USA. voils001@mc.duke.edu
Contemporary Clinical Trials
|July 31, 2012
Summary
Standardizing behavioral intervention dosing terms like duration, frequency, and amount is crucial. This improves understanding of dose-response relationships for effective intervention development and dissemination.
Area of Science:
- Behavioral Science
- Intervention Science
- Public Health
Background:
- Dosing is a critical factor in behavioral intervention effectiveness.
- Current reporting of dosing parameters is often inconsistent, hindering analysis.
- Understanding dose-response relationships is key for optimizing interventions.
Purpose of the Study:
- To propose standardized terminology for reporting behavioral intervention dosing.
- To evaluate the impact of standardized dosing on understanding dose-response relationships.
- To identify challenges in current reporting within the antiretroviral therapy (ART) adherence literature.
Main Methods:
- Reviewed 31 published reports of behavioral interventions for ART adherence.
- Analyzed the reporting of dosing parameters: duration, frequency, and amount.
- Assessed heterogeneity in dosing schedules and control groups.
Main Results:
- Significant under-reporting of dosing parameters was identified in the ART literature.
- Heterogeneity in dosing schedules and control groups complicates dose-response analysis.
- Lack of standardized reporting impedes systematic reviews and optimal dose determination.
Conclusions:
- Standardized reporting of duration, frequency, and amount is essential for intervention development.
- Improved reporting facilitates identification of effective intervention doses.
- Standardization aids efficient implementation of efficacious behavioral interventions in practice.
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