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Updated: May 5, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
Published on: June 7, 2013
Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers
Bérengère Fromy1, Eric Lingueglia, Dominique Sigaudo-Roussel
1Institut de Biologie et Chimie des Protéines, Centre National de la Recherche Scientifique (CNRS) FRE 3310, Lyon, France; Université de Lyon 1, FRE 3310, Lyon, France.
Abstract:
Pressure-induced vasodilation (PIV) delays the decrease in cutaneous blood flow produced by local application of low pressure to the skin, a physiologically appropriate adjustment of local vasomotor function. Individuals without a normal PIV response have a high risk of ulceration. Here we demonstrate that acid-sensing ion channel 3 (Asic3) is an essential neuronal sensor for the vasodilation response to direct pressure in both humans and rodents and for protecting against pressure ulcers in mice.
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