Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic low-dose oral methylglyoxal intake is associated with delayed circadian sleep timing and altered gut microbiota in mice.

Neuroscience letters·2026
Same author

UNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia.

Aging cell·2026
Same author

Sex-specific differences in psychophysiological stress-induced circadian sleep disruption and its impact on glucose metabolism in mice.

Life sciences·2026
Same author

Effects of plain water intake before bedtime on sleep and depressive mood among middle-aged Japanese men.

PloS one·2026
Same author

Wheat Alkylresorcinols Induce Non-Rapid Eye Movement Sleep by Reducing Core Body Temperature in Mice.

Journal of nutritional science and vitaminology·2026
Same author

Time-of-day effect of high-intensity muscle contraction on mTOR signaling and protein synthesis in mice.

Scientific reports·2025

Related Experiment Video

Updated: May 20, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

[Clock genes and clock-controlled genes in mammals].

Katsutaka Oishi1

  • 1Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST).

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 2012
PubMed
Summary

The suprachiasmatic nucleus (SCN) acts as the master circadian pacemaker in mammals. This review covers recent findings on clock genes and their role in SCN and peripheral tissue circadian rhythms.

More Related Videos

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters
07:44

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters

Published on: July 4, 2018

Related Experiment Videos

Last Updated: May 20, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters
07:44

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters

Published on: July 4, 2018

Area of Science:

  • Chronobiology
  • Molecular Biology
  • Genetics

Context:

  • The suprachiasmatic nucleus (SCN) is the central circadian pacemaker in mammals, regulating physiological and behavioral rhythms.
  • Peripheral tissues and isolated cells also exhibit intrinsic circadian oscillators, synchronized by the SCN.
  • The molecular machinery of the circadian clock is conserved across the SCN and peripheral tissues.

Purpose:

  • To review recent advancements in understanding clock and clock-controlled genes in mammals.
  • To highlight the molecular mechanisms underlying circadian rhythms in both central and peripheral tissues.
  • To discuss the identification and function of tissue-specific circadian genes.

Summary:

  • Circadian rhythms in mammals are orchestrated by the suprachiasmatic nucleus (SCN), the master biological clock.
  • Clock genes and their transcriptional-translational feedback loops operate within the SCN and peripheral cells, maintaining rhythmicity.
  • DNA microarray technology has identified numerous tissue-specific circadian genes involved in diverse biological processes.

Impact:

  • Provides a comprehensive overview of current knowledge on mammalian circadian clock genes.
  • Facilitates further research into the genetic regulation of circadian rhythms and their associated biological processes.
  • Enhances understanding of how central and peripheral clocks interact to maintain organismal homeostasis.